Progress on Fyn-mediated phosphorylation of the N-methyl-D-aspartate receptor subtype 2B receptor in the treatment of chronic pain

Abstract

Background The overactivity of N-methyl-D-aspartate (NMDA) receptors in spinal cord dorsal horn plays a critical role in central sensitization of chronic pain. Recent studies indicate that the phosphorylation of NMDA receptors(NR) are tightly regulated by the Src family tyrosine kinase Fyn, through dynamic interactions with various scaffolding proteins in the NR2B subunit of NR. Objective This article aims to further elucidate the mechanism of chronic pain, and explore novel methods for pain management. Content The article focuses on the mechanism of phosphorylation of NR mediated by Fyn, and the essential role of Fyn in the central sensitization of chronic pain. Trend Prevention of the phosphorylation of NR2B-containing NR mediated by Fyn may become a new target for the treatment of chronic pain. Key words: Fyn; N-methyl-D-aspartate receptor; Subtype 2B; Chronic pain