Abstract
The occurrence of thyroid gland is easily affected by iodine deficiency, the enzyme defect, drugs, autoimmune and other factors. The increased incidence of thyroid cancer year by year has threatened the health of the human, which requires to study thyroid gland cancer invasion and metastasis, investigate the molecular mechanism of cancer metastasis, search the differential molecular expression gene, predict the metastatic biomarkers and the intervening treatment target molecule, in order to improve the cure rate and the survival rate. This paper reviews the possible role of long chain non-coding RP11-23J9.4-miRNA-15a-axis inhibiting factor 2-Wnt pathway in the occurrence, development and dedifferentiation of thyroid cancer. Key words: Thyroid neoplasms; Axis inhibiting factor 2; Long chain non-coding; RP11-23J9.4; microRNA-15a
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