Progress of pancreatic acinar cell injury mechanism in biliary acute pancreatitis

Abstract

Biliary acute pancreatitis (BAP) is the most common type of acute pancreatitis (AP), involving high mortality rate, being easy to relapse, and lacking of ideal treatment clinically. Currently, it is considered that the injury of pancreatic acinar cells is an initiating factor in the pathogenesis of BAP and a key factor to affect the occurrence and development of the disease. Therefore, it is important to elucidate the pathogenesis of BAP, that understanding the mechanism of the acinar cells injury. In recent years, several reasearches found it is closely related to the injury of pancreatic acinar cell, that G-protein-coupled bile acid receptor-1 (GPBAR-1) as a specific receptor associated with bile acid induced the injury of pancreatic acinar cell, cytokine cascade activation, intracellular calcium overloading and the mechanism of the acinar cell death. Here is to make a review focused on the recent progress of the pathogenesis of pancreatic acinar cell injury. Key words: Biliary acute pancreatitis; Bile acid; G-protein-coupled bile acid receptor-1; Ca2+ signal; Apoptosis; Necroptosis; Autophagy