Progress of New Antiepileptic Drugs in the Treatment of Epilepsy in Children

Abstract

Epilepsy is one of the most common pediatric neurological diseases, and antiepileptic drug therapy is the preferred method at present. The new antiepileptic drugs (AED) with the advantages of wide spectrum, less adverse reaction, high tolerance and safety than traditional AED, have given physicians new options for the treatment of children with epilepsy. However, due to the lack of global clinical trials in children, most of the drugs, including AED, are lack of clinical efficacy and safety data for children, and just use in children with a dosage of a simple conversion from adult dose, witch neglected children distinction between adults. Recently, several studies suggested evidence-based guidelines for the efficacy and tolerability of the new AED and offered expert opinions, including those concerned with pediatric patients, to facilitate more reasonable selection of the new AED. In this article, we review the progress and evidence-based evidence of common new AED in treatment of epilepsy in children and summarized below. Key words: Epilepsy; Anticonvulsants; Treatment; Child