Abstract
MiRNA is a small non-protein coding RNA that play an important role in gene regulation by targeting the 3'untranslated region of specific target gene mRNA, leading to the degradation of target RNA or inhibition of protein synthesis in post-transcriptional level. Radiation therapy is a main method for cancer treatment. Tumor radiation biological effect is critical in radiotherapy and a core determining factor of tumor radioresistance or radiosensitivity. Recent studies have demonstrated that miRNA can regulate tumor radiosensitivity by affecting DNA damage repair, cell cycle checkpoint, apoptosis, signal transduction pathways and tumor microenvironment etc. miRNA offer potential new approach to complement the radiotherapy for tumor treatment. Key words: MicroRNAs; Radiotherapy, computer-assisted; Radiation tolerance
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