Abstract
MicroRNAs are small, single-stranded and non-coding RNAs.MicroRNAs modulates gene expression by binding themselves to complementary sites of target genes.It had been discovered that microRNAs modulate sepsis in multiple levels.Through targeting Ca2+ /calmodulin-dependent protein kinase Ⅱ, miR-152 and miR-148 impair innate response and antigen presentation, and also suppress proliferation of antigen specific CD4+ T cells; miR-29 family regulate cellular immunity through setting the threshold in thymic involution; MicroRNA-17-92 plays a causative role in B cell lineage; miR-146 and miR-155 down-regulate proinflammatory cytokines through suppressing components of pattern recognition receptors, while miR-132 through acetylcholinesterase degeneration.miR-124 degenerates mRNA of glucocorticoid receptorαand results in glucocorticoid resistant in treatment of sepsis.Immune regulation of microRNAs in sepsis is briefly described in this paper. Key words: MicroRNA; Sepsis; Immunomodulation
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