Abstract
Exosomes are vesicle-like bodies with a diameter of 30 - 100 nm. They mediate intercellular signal transmission by transmitting their proteins, microRNAs (miRNAs) and long non-coding RNA (lncRNAs) to recipient cells. Esophageal cancer is a common malignant tumor of digestive system with high incidence rate and mortality. It lacks typical symptoms at early stage and has no mature early diagnosis. Therefore, if exosomes can be used as markers for early diagnosis, prognosis and efficacy evaluation of esophageal cancer, it can provide a new strategy for early diagnosis of esophageal cancer patients and the development of effective anti-cancer drugs in the future. in this research, we study the effect of exosomes in regulating the growth and metastasis, epithelial-mesenchymal transition, angiogenesis, tumor microenvironment and chemoresistance of esophageal squamous cell carcinoma (ESCC), which lays a solid foundation for the comprehensive understanding of the application of exosomes on the diagnosis and treatment of ESCC.
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