Progress of EGFR targeted therapy for oral cancer

Abstract

Because of some uncertain factors such as eating habits and smoking, oral cancer has become one of the serious diseases of the oral and maxillofacial region. Especially in some Chinese cities where betel nut chewing is customary, the incidence of oral cancer has been high. Today, the main treatment methods are still traditional surgical excision, radiation and chemotherapy. However, with the development of medical technology, gene-targeted therapy has become the most important research object. Gene targeting technology is mainly targets the treatment of cancer organ cells, reducing the damage of traditional treatment methods on other areas without lesions. At present, the epidermal cytokine EGFR has been the most studied, and some research results have been put into clinical application. However, in terms of targeted therapy, the development of technology is still incomplete and immature. This article mainly discusses the pathogenic mechanism of EGFR in oral cancer, the synergistic effect of EGFR and other factors on the development of oral cancer, and the research results of EGFR-targeted therapy and combination therapy for oral cancer. The significance of this study is that based on these discussions, it provides reference opinions for treatment that can achieve a good prognosis for oral cancer patients and alleviate the pain of oral cancer patients, and evaluate the current development status of clinical application of EGFR targeted therapy for oral cancer. At present, the targeted therapy technology of oral cancer is still immature. In the future, the role of other factors in the development of oral cancer can be studied, and the influence of the combination of targeted therapy and other therapeutic methods on the treatment results of oral cancer can be studied.