Abstract
亲环素A（cyclophilin A, CypA）作为亲环素家族中最重要的一员，在自然界中广泛表达，发挥着肽基脯氨酰顺反异构酶（peptidyl-prolyl cis-trans isomeras, PPⅠase）活性和分子伴侣效应，辅助细胞内蛋白质的正确折叠，参与免疫抑制，介导炎性反应，平衡细胞内外胆固醇。随着对CypA认识的加深，人们逐渐意识到它与恶性肿瘤之间的密切联系。CypA最先被发现在肺癌中高表达，具有促进肺癌细胞生长、抑制凋亡、介导侵袭转移等作用，可能成为一个肺癌的早期诊断和治疗的新靶点。
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