Abstract

Chronic hepatitis B caused by hepatitis B virus (HBV) infection is a severe global public health problem.Current anti-viral drugs are effective in suppressing HBV replication but fail to clear the virus in most cases.How to effectively and comprehensively stimulate patients' immune system and reconstruct immunity against HBV may be the key to eliminate chronic infection.Therapeutic HBV vaccine is promising to become a new strategy.A variety of therapeutic HBV vaccines are being developed,including protein,peptide,DNA,and autologous dendritic cell vaccines.The progress of clinical research on the vaccines and their combined application with anti-viral drugs is summarized in this review. Key words: Hapatitis B vaccines ; Hepatitis B virus ; Hepatitis,chronic ;

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