Abstract
The cytochrome P450 4A and 4F family catalyze the metabolism of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).20-HETE has two contradictory effects in the development of hypertension.One is prohypertension resulting from constriction of the small arteries.The other is anti-hypertension caused by inhibition of sodium reabsorption.In the animal modes of hypertension,they suggested that 20-HETE is not only closely associated with hypertension,but also accompanies with blood glucose abnormalities.Furthermore,the abnormal 20-HETE level was also found in some diabetic animal models and human affected with diabetes.In this paper,20-HETE on blood pressure and glucose regulation was reviewed. Key words: 20-HETE ; Blood pressure ; Blood glucose
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