Progress in Toll like receptor agonists as adjuvants in vaccine design

Abstract

Innate immune cells have a critical role in defense against infections and diseases. Central to this is the broad specificity with which they can detect pathogen-associated patterns and danger-associated patterns via the pattern recognition receptors (PRRs) they express. TLR is one of the most largely studied families of PRRs. Activation of TLR promotes both innate inflammatory responses and the induction of adaptive immunity. Given the characteristics of TLR, various Toll like receptor agonists are used in vaccine design to accelerate the immune response and produce long-lasting protection. Key words: Toll like receptor; Vaccine; Adjuvant