Abstract
Compared with mature cells, human pluripotent stem cells (PSCs) have cellular and organ functions closer to those of primary cells. In infectious skin disease research, PSCs provide accurate pathophysiology for exploring the specific cellular and molecular mechanisms of refractory disease. Herein, we review the latest knowledge of human embryo model construction under laboratory conditions, focusing on important mycobacterial diseases, such as leprosy and tuberculosis. Moreover, an analysis of SARS‐CoV‐2 research using human PSCs or organoids shows that human PSCs play an important role in modelling dermatological infectious diseases and their complex mechanisms.
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