Abstract
Prognosis of thyroid cancer is generally more optimistic,however many tumors (30％) will de-differentiate and become refractory to radioactive iodine,the rate of 10 year survival will be reduced to 30％-40％.Recent data have shown that silencing of thyroid-stimulating hormone receptor (TSHR) appears to be related to the most aggressive behavior of thyroid cancer,TSHR expression is reduced in differentiated thyroid cancer while is lack in de-differentiated thyroid cancer; in vitro experiments,human TSHR gene transfection in thyroid carcinoma cell line can promote the rate of iodine uptake and the expression of the gene of iodine uptake.From this it is clear that TSHR plays an important role in the onset and the development of thyroid cancer.This article briefly reviewed the TSHR gene and protein,the role of TSHR in thyrocyte and the onset of the thyroid cancer,the signaling pathways that TSHR participate in and analyzed the role of TSHR in de-differentiated thyroid cancer. Key words: Thyroid neoplasms; Receptors, thyrotropin; Gene silencing; MAP kinase signaling system
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