Abstract

肺癌在我国的发病率和死亡率均排名第一,肿瘤发生转移往往预示患者预后不良。其中,非小细胞肺癌(non-small cell lung cancer, NSCLC)的淋巴转移是导致患者预后不良的重要因素。淋巴管生成是促进肿瘤淋巴转移的重要环节。本文综述肿瘤相关淋巴管生成的分子机制,探讨肿瘤微环境与淋巴管内皮细胞间的相互作用,并总结了目前关于非编码RNA对于肿瘤相关淋巴管生成调控机制的研究及进展,以期为NSCLC相关淋巴管生成的研究与诊疗提供新的思路。

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