Abstract

Since a number of genes have been discovered, which are associated with the effect of drug therapy, the development of personalized medicine is enhanced.Meanwhile, personalized test played an important role in choosing proper medicine.Herein, the status of detection of V-ki-ras2 Kirsten rat sarcoma viral oncogene homolog(Kras), epidermal growth factor receptor(EGFR), B-Raf and v-Raf murine sarcoma viral oncogene homolog B1(BRAF) mutation is concluded, moreover, the association between the mutation test and the effect of cancer therapy is summarized.(Chin J Lab Med, 2012,35:971-977) Key words: Proto-oncogene proteins; Ras proteins; Receptor;  epidermal growth factor; Personalized medicine; Mutation

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