Progress in the application of tumor DNA in the diagnosis and treatment of esophageal cancer

Abstract

With the development of precision medicine in the field of tumor, thanks to the latest screening technology, the demand for real-time monitoring of tumor is increasingly high. Traditional tissue biopsy is not suitable for repeated due to clinical problems such as puncture clinical risk and tumor heterogeneity. Ultrasound, endoscopy and other imaging examinations are highly subjective, and it is difficult to detect small lesions, and increasingly unable to meet the requirements of real-time monitoring. However, circulating tumor DNA, with its advantages of simple sample acquisition, small trauma, repeatability and real-time monitoring efficacy, has an important application prospect in tumor diagnosis and treatment. Based on the latest reports at home and abroad, this paper reviews the research progress of circulating tumor DNA in the early diagnosis, treatment and prognosis of esophageal cancer. Key words: Esophageal neoplasms; DNA, neoplasm; Diagnosis