Progress in the application of gene editing technology in cancer treatmentstaking CRISPR as an example

Abstract

The background of CRISPRs development lies in the long-standing need for precise gene editing tools, which culminated in the revolutionary CRISPR-Cas9 system in 2012. This technology has had profound impacts on biology, medicine, and biotechnology, offering versatile applications in gene therapy, agriculture, and research across eukaryotes, prokaryotes, and archaea. In the context of cancer research, CRISPR has shown promise in understanding cancer biology, identifying therapeutic targets, enhancing immunotherapy, and potentially enabling early cancer diagnosis and personalized treatment. However, challenges remain, including the need to enhance precision, address ethical concerns, and conduct rigorous clinical trials. This article examines CRISPRs advancements in cancer treatment and concludes that, when compared to other gene editing methods, it offers benefits like robust targeting, easy operation, and efficient editing. Based on these benefits, the application prospect of CRISPR in enhancing personalized medicine, drug development, and cancer treatment is also discussed in this article. This article highlights the need for addressing precision and safety issues and the importance of interdisciplinary collaboration and stringent regulation in realizing the full potential of CRISPR in cancer treatment. In conclusion, CRISPR offers promising avenues for improving cancer treatment by enabling precise gene editing and personalized therapies. Despite the challenges, continuous advancements in technology and research, along with stricter regulation, will ensure the safe and effective use of CRISPR in cancer, providing hope for cancer patients and shaping the future of oncology research.