Abstract
<p indent="0mm">Surface-enhanced Raman spectroscopy (SERS) has the characteristics of high sensitivity and high throughput. As a non-destructive biological imaging technology, SERS imaging has been widely used in biological analysis and imaging, such as quantification, structural analysis and functional tracking of glycan on cell surface, microRNA and protein in cells, analysis of cellular pH, describing the edges of tumor tissues to guide surgical resection, and quick detection of bacteria and bacteria communications. SERS imaging can avoid the strong molecular self-fluorescence in living systems and the photobleaching phenomenon in fluorescence imaging, and achieve highly sensitive and highly throughput bioimaging with fingerprint spectra of different Raman beacons. Combined with other imaging technologies (such as magnetic resonance imaging and photoacoustic imaging), SERS imaging is expected to be applied in the research of more complex living systems. This article reviews the recent research progress in surface enhanced Raman imaging of cellular functional molecules and its applications.
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