Progress in resistance mechanisms to -lactamase inhibitors

Abstract

One of the main causes of death for people is bacterial infections. Among them, enzyme-mediated antibiotic resistance has been a serious problem and is a serious threat to public health security. The use of enzyme inhibitors can effectively deal with this problem, and antibiotics can be used in conjunction with inhibitors to partially restore their activity and enable them to function as antibacterial agents. Therefore, the development of new enzyme inhibitors is particularly important. In this paper, -lactamases were analyzed and studied, and the resistance mechanisms of two different types of -lactamases were reviewed. In addition, it is summarized that the enzyme inhibitors that can block the antibacterial effect of the enzyme and can reactivate the activity of the antibiotic. However, there is still a gap in the research of metallo--lactamases inhibitors, which is also the main direction of research and development in the future.