Abstract

Antibody fusion protein has become one of the most successful drugs in bioengineering therapeutics, among which Fc fusion protein is a type of protein constructed by combining the Fc region of antibody with the active component of protein drug using genetic engineering platform technology. While Fc fusion protein was originally generated to extend its half-life, many researches have indicated that the Fc part also participates in immune regulations and results in immunological effect. Along with the rapid advance of biotherapeutic drugs, Fc fusion protein drugs also made great progress. This article briefly summarized the research progress of therapeutic Fc fusion protein drugs in aspects of design goal, design principle, mechanism, and quality control. Key words: Recombinant fusion proteins; Immunoglobulin Fc fragments; Drug design; Quality control

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