Abstract
C-reactive protein (CRP) is a highly evolutionarily conserved protein of innate immune system, which consists of five identical subunits that are non-covalently associated as a cyclic pentamer. CRP is not only recognized as a marker, but also directly contributes to the inflammatory process. CRP exists in two major conformationally distinct forms, i.e. native pentameric CRP (pCRP) and modified/monomeric CRP (mCRP). Dissociation of pCRP into mCRP occurs within the inflammatory microenvironment, which may contribute to development of local inflammatory response. Here we review recent progress in the research of conformational change of CRP, which has been related to its distinct functional properties, and also its pro-inflammatory mechanism.
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