Abstract
Hair is a protective appendage on the body that is considered accessory structure of the integument. Hair follicle development takes place during fetal skin development and relies on tightly regulated ectodermal-mesodermal interactions. The morphological changes of the hair cycle have been very clear that hair morphogenesis and epidermal development are orchestrated by an array of growth factors. In this review, we summarize the major growth factors involved in promoting growth of hair follicles.
Highlights
The skin is the body's largest organ, covering the body surface and in contact with the outside world. It is a composition by the keratinized stratified epidermis and collagen-rich dermal connective tissue, which contains a subsidiary organ of the hair follicles, sebaceous glands, sweat glands and nails, derived from the epidermis
It has been reported that the growth factors, such as Epidermal Growth Factor (EGF), Transforming Growth Factor-β (TGF-β), Insulin-like Growth Factor (IGF)-1, Hepatocyte Growth Factor (HGF), Keratinocyte Growth Factor (KGF), Vascular Endothelial Growth Factor (VEGF) and so on, participate in the hair follicle cycle regulation and promote hair growth. We summarize their progress at home and abroad in the past few years
Studies have shown that ErbB1 as an important growth factor receptor and its ligand EGF exist in Outer Root Sheath (ORS) of the mature hair follicle and play an important role in the regulation of hair follicle growth cycle
Summary
The skin is the body's largest organ, covering the body surface and in contact with the outside world. The growth factor, as an important link of coordination genes secreted by the body and the environment, plays a vital role in the growth and regulation of the hair follicle.
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