Progress in Proteomic Mass Spectrometry Studies on the Effects of Borneol and Menthol as Enhancers on Corneal Injury Repair

Abstract

Cornea transparent, avascular tissue, is an important part of the refractive function. Corneal injury is the destruction of the corneal structure caused by blunt eyeball, external force, high pressure gas or fluid hitting the cornea. Common in boxing injury, ball injury, stone injury, head collision, etc. The external force directly acts on the formation of the cornea, mainly manifested as vision loss, pain, photophobia, tears, ciliary congestion and contusion corneal edema. Mild corneal damage can be restored under the strong self-healing ability of the corneal epithelium. If serious corneal damage, the corneal stromal layer will leave a scar on the cornea to affect the vision, but also likely to cause related complications, and even lead to complete blindness. Recent studies have shown that corneal alkali burn is one of the most common eye injuries. Due to the strong corrosion of alkaline substances, it can cause degeneration and dissolution of corneal tissue proteins. The lipophilic properties of alkaline substances make it difficult to limit the damage site and easy to form ulcers. In this paper, we discuss the borneol and menthol on the corneal damage repair mass spectrometry, through the influence of borneol and menthol on corneal damage repair and the preliminary test of ice and menthol can be used, in order to provide a new clinical treatment of corneal damage to the new research direction.