Abstract
Patent ductus arteriosus is one of the common complications in the premature infants, which lead to or worsen respiratory distress, chronic pulmonary disease, intraventricular hemorrhage and necrotizing enterocolitis.It is associated with an increase in mortality and sequelae of preterm infants.The various factors contributing to an patency of the ductus arteriosus in the preterm infants are involved in: insufficient histological development of ductus arteriosus, failure of remodeling the ductus, abnormal sensitivity of the ductus to oxygen and vasoactive substances, and genes.It has been proposed a new idea that platelet induces or drives the closure of patent ductus arteriosus. Key words: Preterm infant; Patent ductus arteriosus; Pathogenesis
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