Progress in mRNA cancer vaccine research, current limitations, application and future

Abstract

Cancer has always been an important topic in the medical field, and human beings have been fighting against cancer for hundreds of years. The methods of cancer treatment have also made great progress and innovation. At present, in addition to the traditional cancer treatment, targeted drug delivery treatment, precision medicine, immunotherapy, etc., are also emerging continuously. Especially in recent years, immunotherapy have received special attention. As an important method of immunotherapy, cancer vaccine has a great prospect, especially mRNA vaccine which belongs to class of nucleic acid vaccine. This review discusses the mechanism of mRNA cancer vaccines playing a role in cancer therapy, and their significant advantages over other types of vaccines. In addition, this review summarizes the current limitations of mRNA vaccines and solutions to these problems. Researchers can also learn about the current application status of mRNA vaccines through this review. Overall, this paper can help readers to have a comprehensive understanding of all aspects of mRNA vaccine, which is of great value to readers who want to conduct further research on mRNA vaccine.