Abstract
Osteosarcoma is a primary malignant tumor originating from mesenchymal tissue. It has the characteristics of high malignancy, easy metastasis (common lung metastasis) and poor prognosis. Metastasis is the main cause of treatment failure and poor prognosis. Although the treatment of osteosarcoma has made some progress in these decades, the 5-year survival rate of patients with metastasis has not increased much. This review explores the molecular mechanism of osteosarcoma metastasis, the current research progress of therapeutic drugs, immunotherapy and targeted therapy, and provides ideas for the treatment of osteosarcoma.
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