Progress in Mediating Cell Functions on Honeycomb Substratum

Abstract

The clinic needs of advanced biomaterials for tissue regeneration have driven the study on pores, ridges, fibers, and other microstructured features to mimic the topographies available on basement membranes. Recently, the honeycomb topography with well-ordered pores has drawn increasing attention due to its significant influence on cell functions and the effects can be cell type dependent. To gain potential application in tissue regeneration, we have to obtain good understanding of the interaction between honeycomb pores and cells. In this review article, we will introduce the deep meanings of research on honeycomb topography, review several useful approaches to fabrication of honeycomb patterns, describe topographical influence on application in biomaterials, and discuss the regulation of cell function on honeycomb patterns.