Abstract
Specific immunotherapy(SIT)is the most effective therapy for allergies.Although specific immunotherapy has existed for more than 90 years and has made a great progress,its mechanism is not well defined.Early studies focused on the circulating antibodies and effector cells.At present.the research of the mechanism mainly concentrates on the immune therapy on T cells role and a series of cytokines arising from the change,CD4+ regulatory T cells subsets,modified APC induction of immune tolerance,aggregation mechanism of immune effector cells,restructuring allergens under the support of monoclonal antibody technique,allergens DNA vaccines,allergens coupling adjuvants.This essay is a review of progress in mechanism of specific immunotherapy. Key words: Specific immunotherapy; Mechanism
Published Version
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