Abstract
Lung cancer and chronic obstructive pulmonary disease (COPD) are among diseases with the highest morbidity and mortality worldwide. Environmental and genetic factors are commonly involved in the etiology of COPD and lung cancer. There are more reports of epigenetic changes in the genome evoked by oxidative stress reaction due to smoking in environmental factors than that of inherited genetic. Epigenetic mechanisms can play an important role in many complex diseases, and epigenetic regulation including DNA methylation, covalent histone modifications and microRNAs is an important biomarker in the diagnosis of COPD and lung cancer. This review particularly emphasizes on the association between DNA methylation and covalent histone modifications in COPD and lung cancer. Key words: DNA Methylation; Covalent Histone Modification; Lung Cancer; COPD; Epigenetic
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