Progress in diagnosis and treatment of eosinophilic cystitis in children

Abstract

Eosinophilic cystitis(EC) is a kind of bladder proliferation disease and rather rare in children.The pathological character shows invasion of huge amounts of eosinophil granulocytes in the total bladder wall.Although it has unknown etiology, but it is widely believed to be involved in allergy.It can appear at any age with a higher incidence in male.Since it was first reported in 1960, there are a total of more than 300 patients reported, about 70 of them are children.The major clinical manifestations are urinary frequency, suprapubic pain during miction, gross or microscopic hematuria, dysuria, nocturia and so forth.Some patients with increased eosinophils in the peripheral blood.It is essential to examine blood routine, urine routine, imaging tests and cystoscopy and defining diagnosis depends on histopathologic biopsy.The self-limiting of EC in children is much stronger.The main therapies for EC are application of corticosteroids, antihistamines and so forth, while feasible operation should be treated when severe complications appear or the disease progress. Key words: Eosinophilic cystitis; Diagnosis; Treatment; Urodynamic study