Progress in development of bioderived materials for dermal wound healing.

Lin-Cui Da,Yi-Zhou Huang,Hui-Qi Xie

doi:10.1093/rb/rbx025

Abstract

Treatment of acute and chronic wounds is one of the primary challenges faced by doctors. Bioderived materials have significant potential clinical value in tissue injury treatment and defect reconstruction. Various strategies, including drug loading, addition of metallic element(s), cross-linking and combining two or more distinct types of materials with complementary features, have been used to synthesize more suitable materials for wound healing. In this review, we describe the recent developments made in the processing of bioderived materials employed for cutaneous wound healing, including newly developed materials such as keratin and soy protein. The focus was on the key properties of the bioderived materials that have shown great promise in improving wound healing, restoration and reconstruction. With their good biocompatibility, nontoxic catabolites, microinflammation characteristics, as well as their ability to induce tissue regeneration and reparation, the bioderived materials have great potential for skin tissue repair.

Highlights

The skin, which is composed of the epidermis, the dermis and subcutaneous tissue (Fig. 1a), plays a critical role in ensuring human health, for it protects tissues and organs from physical, mechanical, chemical and microbial damage [1]
We describe the recent developments made in the processing of bioderived materials employed for cutaneous wound healing, including newly developed materials such as keratin and soy protein
The use of natural polymers, including natural polysaccharide polymers and natural proteins, is an important direction in the development of tissue engineering scaffolds, because these materials exhibit high cellular affinity, and their use does not result in chronic inflammation, immunological reactions, or toxicity [7]

Summary

Introduction

The skin, which is composed of the epidermis, the dermis and subcutaneous tissue (Fig. 1a), plays a critical role in ensuring human health, for it protects tissues and organs from physical, mechanical, chemical and microbial damage [1]. The use of natural polymers, including natural polysaccharide polymers (e.g. cellulose, chitosan and hyaluronic acid, among others) and natural proteins (e.g. silk fibroin, collagen and fibrin glue, among others) (see Fig. 2), is an important direction in the development of tissue engineering scaffolds, because these materials exhibit high cellular affinity, and their use does not result in chronic inflammation, immunological reactions, or toxicity [7].

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