Progress in Biomedical Applications of Functionalized Nucleic Acid Nanodevices (NANDs)

Abstract

AbstractDNA and RNA are building blocks with excellent programmability for nanoscale assembly. Owing to their appealing properties such as precision in bottom‐up fabrication, enhanced stability and cellular internalization, designed nucleic acid nanodevices (NANDs) have been widely explored in biomedical research. Compared with pristine nucleic acids, chemically modified NANDs exhibit a wider spectrum of applicability. In this Focus Review, we highlight recent advances of NANDs functionalized with small molecules, peptides/proteins or inorganic materials, and elucidate their promising future for biomedical application.