Progress in Application of Dual/Multi-Template Molecularly Imprinted Polymers

Abstract

The molecularly imprinted polymers (MIPs) prepared from a single template theoretically only have selectivity for the template molecule itself, which limits its application. Dual/multi-template molecularly imprinted polymers (D/MMIPs) not only have the selectivity toward template but also increase the throughput of separation analysis and the range of applications in actual samples. In this review, application progresses of multi/dual-imprinting technology in pharmaceutical analysis, environmental pollutant analysis, biological macromolecule analysis, extraction of active ingredient from natural product, catalysis, transport agent, denitrifying and desulfurizing agent, molecular and ion analysis are discussed. These progresses will advance the further development of molecularly imprinting technology, and D/MMIPs will be used in more fields. This review discusses the application progress of dual/multi-template molecular imprinted technology in five aspects, including pharmaceutical analysis, environmental pollutant analysis, biological macromolecule analysis, natural product active ingredient extraction and other fields. It promotes the understanding of the applications of dual/multi-template molecular imprinting techniques.