Progress and Puzzles in Psychedelic Therapy

Abstract

There has been a remarkable resurgence of interest in the therapeutic potential of psychedelic drugs to treat serious psychiatric disorders. Yet the number of controlled studies evaluating the clinical efficacy of these drugs remains small, and the studies face significant methodological challenges. The challenges include minimizing the role of expectancies; selecting the most appropriate control condition, the most sensitive outcome measure(s), and the best dosing regimens; and identifying the role of concomitant psychotherapy.