Progress and prospect of treatment for ocular Behçet disease

Abstract

Ocular Behcet disease, which usually presents as panuveitis, with characteristic of vision impairment and relapse, is one of the most refractory uveitis entities.Usually, one or more conventional immunosuppressive agents, such as glucocorticoid, ciclosporin, chlorambucil, cyclophosphamide, etc, are needed in disease management.However, long-term use of immunosuppressive agents would result in severe adverse effects.New biologics, such as interferon, antitumor necrosis factor agents, interleukin or its receptor antagonists, provide new therapeutic approaches to the treatment for this disease.This paper reviewed the conventional therapies and biologics applied in ocular Behcet disease. Key words: Behcet disease, Uveitis; Treatment; Immunosuppressive agent; Biologics