Programmed cell death: apoptotic versus necrotic

Abstract

Event Abstract Back to Event Programmed cell death: apoptotic versus necrotic Slavica Krantic1* 1 INSERM U901, Parc Scientifique de Luminy, INMED, France The discovery of apoptosis, considered until recently as the sole form of programmed cell death (PCD), raised much hope for intervention in neurodegenerative diseases. However, inhibiting apoptosis has turned out not to be as efficient as initially expected, thus pointing to the importance of additional PCDs in neurodegeneration. Among recently discovered new PCD phenotypes, morphological and biochemical features of neuronal death in degenerative diseases are reminiscent of apoptosis-like PCD and programmed necrosis. In contrast to apoptosis, these PCDs do not rely on activation of proteolytic enzymes known as caspases. The main mediator of caspase-independent PCDs is Apoptosis-Inducing Factor (AIF), which after calpain-mediated cleavage, translocates from mitochondria to the nucleus to trigger cell death. Although AIF-mediated apoptosis-like PCD and programmed necrosis share many similarities, only in programmed necrosis there is an early permeabilization of the plasma membrane resulting in the release of lactate dehydrogenase (LDH) in the extracellular medium.Accumulating in vitro and in vivo evidence suggests that apoptosis-like PCD occurs in cerebral ischemia. Moreover, it has been demonstrated that a great majority of neurons die by this PCD pathway, whereas classical apoptosis represents a minor cell death phenotype. Involvement of apoptosis-like PCD in long-term degenerations such as Parkinson’s and Alzheimer’s diseases has also been reported. By contrast, there is yet no explicit demonstration of the involvement of programmed necrosis in neuronal death. We will discuss the need of precise discrimination between the involvement of apoptosis-like PCD and programmed necrosis, and how such knowledge can be used for more efficient neuroprotection. Supported by INSERM, FRSQ and CIHR. Keywords: AIF, apoptosis-like cell death, programmed necrosis Conference: 3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009. Presentation Type: Oral Presentation Topic: Symposium 19 – Neuronal loss by programmed cell deaths: new players in neurodegenerative diseases Citation: Krantic S (2009). Programmed cell death: apoptotic versus necrotic. Front. Neurosci. Conference Abstract: 3rd Mediterranean Conference of Neuroscience . doi: 10.3389/conf.neuro.01.2009.16.076 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 20 Nov 2009; Published Online: 20 Nov 2009. * Correspondence: Slavica Krantic, INSERM U901, Parc Scientifique de Luminy, INMED, 13331 Marseille, France, slavica.krantic@inmed.univ-mrs.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Slavica Krantic Google Slavica Krantic Google Scholar Slavica Krantic PubMed Slavica Krantic Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.