Abstract
Abstract PDCD4 (programmed cell death protein 4), an inhibitor of protein transcription and translation, is involved in tumor and inflammation diseases. However, its underlining mechanisms remain unclear. Autophagy, an evolutionarily conserved catabolic process, is reported to regulate survival and death of cells. Here, we demonstrated that PDCD4 inhibits autophagy in multiple cells including immune cells and tumor cells, by which it controls cell fate. Mechanically, PDCD4 suppressed translation of an essential autophagy related gene ATG5 by its MA-3 domain. Our data indicate that PDCD4 is endogenous inhibitor of Atg5.
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