Programmable Transcranial Magnetic Stimulation: A Modulation Approach for the Generation of Controllable Magnetic Stimuli.

Majid Memarian Sorkhabi,Daniel J Rogers,Timothy Denison,Moaad Benjaber,Timothy O West,Karen Wendt

doi:10.1109/tbme.2020.3024902

Majid Memarian Sorkhabi, Daniel J Rogers + Show 4 more

Open Access

https://doi.org/10.1109/tbme.2020.3024902

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Abstract

A transcranial magnetic stimulation system with programmable stimulus pulses and patterns is presented. The stimulus pulses of the implemented system expand beyond conventional damped cosine or near-rectangular pulses and approach an arbitrary waveform. The desired stimulus waveform shape is defined as a reference signal. This signal controls the semiconductor switches of an H-bridge inverter to generate a high-power imitation of the reference. The design uses a new paradigm for TMS, applying pulse-width modulation with a non-resonant, high-frequency switching architecture to synthesize waveforms that leverages the low-pass filtering properties of neuronal cells. The modulation technique enables control of the waveform, frequency, pattern, and intensity of the stimulus. A system prototype was developed to demonstrate the technique. The experimental measurements demonstrate that the system is capable of generating stimuli up to 4 kHz with peak voltage and current values of ±1000 V and ±3600 A, respectively. The maximum transferred energy measured in the experimental validation was 100.4 Joules. To characterize repetitive TMS modalities, the efficiency of generating consecutive pulse triplets and quadruplets with interstimulus intervals of 1 ms was tested and verified. The implemented TMS device can generate consecutive rectangular pulses with a predetermined time interval, widths and polarities, enables the synthesis of a wide range of magnetic stimuli. New waveforms promise functional advantages over the waveforms generated by current-generation TMS systems for clinical neuroscience research.

Highlights

T RANSCRANIAL magnetic stimulation (TMS) is an important tool used by researchers to study the central and peripheral nervous systems, and by clinicians to diagnose and treat diseases such as depression, stroke and pain
Repetitive TMS protocols, where stimulation pulses are provided in rapid succession, are growing in popularity; but generating consecutive and constant stimuli at high rates a challenging for present-day TMS systems
The programmable TMS (pTMS) was tested with a link voltage of VDC = 1000 V and peak coil current up to 3600 A

Summary

Introduction

T RANSCRANIAL magnetic stimulation (TMS) is an important tool used by researchers to study the central and peripheral nervous systems, and by clinicians to diagnose and treat diseases such as depression, stroke and pain. The choice of specific TMS stimulation parameters (e.g. timing of pulse sequences) can have either inhibitory or facilitatory effects on brain networks, including induction of long-lasting neuroplasticity [2], [3]. Repetitive TMS (rTMS) protocols, where stimulation pulses are provided in rapid succession, are growing in popularity; but generating consecutive and constant stimuli at high rates a challenging for present-day TMS systems. Available TMS technology limits the possibilities for novel stimulation paradigms in neuroscientific experiments. Many of these limitations are inherent in the physical principles by which particular TMS technologies operate. The technical limitations of existing methods may limit their clinical effectiveness, and certainly constrain their potential for TMS stimulation in research

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