Prognostic values of LDH and Hematological factors in Patients with Sudden Hearing Loss

Abstract

Objective: In our study, we aimed to evaluate the relationship between Lactate Dehydrogenase and hematological parameters, neutrophil, Neutrophil lymphocyte ratio, platelet lymphocyte ratio, and mean platelet volume serum levels in patients with Sudden sensorineural hearing loss prognosis. Methods: 60 patients were hospitalized and treated for Sudden Hearing Loss at Dicle University Hospital Ear Nose Throat Clinic between May 2013 and April 2020, and 60 healthy individuals without any health problems were included in the study. Pretreatment peripheral blood was drawn from all subjects, followed by routine blood cell analysis. The absolute numbers of neutrophils, lymphocytes, and platelets in peripheral blood were obtained, and the Neutrophil lymphocyte ratio, platelet lymphocyte ratio, and mean platelet volume of each case were calculated. Results: A total of 120 participants, including 60 Sudden sensorineural hearing loss patients case group and 60 healthy individuals in the control group, were included in the study. The median age of the case group was 46.0 (29.0-55.0), and the control group was 48.0 (33.5-58.5), and no statistically significant difference was found between the groups in terms of age (p = 0.191). The median Lactate Dehydrogenase, Neutrophil, and Neutrophil lymphocyte ratio of the case group was significantly higher than the control group (p <0.05). There was no significant difference between the groups in terms of thrombocyte, mean platelet volume, lymphocyte, platelet lymphocyte ratio, body mass index, and gender (p> 0.05). Conclusion: We think that the increase in Lactate Dehydrogenase level may be a poor prognostic factor in patients with sudden hearing loss that does not improve. In addition, we believe that the increase in neutrophil count and Neutrophil lymphocyte ratio is quite significant but cannot be considered a poor prognostic factor.