Abstract
Objective: The aim of this study was to explore the prognostic value of serum soluble B7-H4 (sB7-H4) levels in patients with non-small cell lung cancer (NSCLC).Methods: Serum specimens from 316 NSCLC patients and 240 healthy controls were collected. The concentrations of sB7-H4 were measured by ELISA.Results: The levels of sB7-H4 in NSCLC patients were significantly higher than that of the controls (P<0.01). Multivariate survival analysis indicated that sB7-H4 was an independent prognostic indicator of overall survival and progression-free survival (P<0.01).Conclusions: Measurement of serum sB7-H4 might be a useful prognostic biomarker for NSCLC.
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