Abstract
In the last few years, V-domain Ig-containing suppressor of T cell activation(VISTA) has been reported as a prognostic biomarker in articles including various solid tumours. However, their conclusions have been controversial. For this reason, we performed this meta-analysis to further verify the prognostic value of VISTA in solid tumours. All relevant literature was identified from PubMed, Embase, the Cochrane Library and Web of Science. Ten studies, including 2, 440 patients, were eligible for the analysis. The pooled results showed that high expression of VISTA was associated with favourable overall survival (OS) than that seen with low expression of VISTA (7 studies, hazard ratio (HR) = 0.75, 95% confidence interval (CI): 0.66–0.86, P < 0.001). In addition, high expression of VISTA significantly correlated with high numbers of CD8 (+) tumour infiltrating lymphocytes (TILs) (3 studies, risk ratio (RR) = 1.80, 95% CI: 1.41–2.31, P < 0.001). In conclusion, these results indicate that VISTA is a potential prognostic biomarker in solid tumours.
Highlights
In the last few years, V-domain Ig-containing suppressor of T cell activation(VISTA) has been reported as a prognostic biomarker in articles including various solid tumours
To further analyse the possible factors that may affect the prognostic value of VISTA in solid tumours, we researched the correlation between the expression of VISTA and patients’ clinicopathological characteristics
Our results revealed that high expression of VISTA was associated with better overall survival (OS)
Summary
In the last few years, V-domain Ig-containing suppressor of T cell activation(VISTA) has been reported as a prognostic biomarker in articles including various solid tumours. High expression of VISTA significantly correlated with high numbers of CD8 (+) tumour infiltrating lymphocytes (TILs) (3 studies, risk ratio (RR) = 1.80, 95% CI: 1.41–2.31, P < 0.001) These results indicate that VISTA is a potential prognostic biomarker in solid tumours. A number of studies have reported the expression of VISTA in the tumour microenvironment of human solid tumours, and these studies found that VISTA was a potential prognostic biomarker associated with patients’ survival. Our results indicated that high expression of VISTA, compared with low expression of VISTA, correlated with better OS and high numbers of CD8 (+) tumour infiltrating lymphocytes (TILs)
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