Abstract
Antihypertensive therapy may lead to a decrease in pulse pressure (PP), which does not necessarily parallel that of systolic and diastolic blood pressure (BP).1 A spontaneous increase in PP over time has been associated with subsequent cardiovascular events.2,3 However, the prognostic benefits of treatment-induced PP reduction compared with the reduction in steady BP components (systolic, diastolic, and mean) remain to be determined in prospective outcome studies. In the setting of the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA) study,4,5 we undertook the present analysis to assess the prognostic significance of changes in PP and mean BP induced by antihypertensive treatment in subjects who attended the pretreatment and follow-up visits and were free of cardiovascular disease. We measured 24-hour ambulatory BP, which is superior to office BP for cardiovascular risk stratification in subjects with essential hypertension.4,6,7 In particular, ambulatory PP is a stronger risk marker than office PP.7
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
