Abstract
BackgroundThe aim of this study was to examine the Tpeak-Tend (Tpe/corrected Tpe) interval, which is an indicator of transmural myocardial repolarization, measured non-invasively via electrocardiogram in patients with acute pulmonary embolism (PE), and to investigate the relationship with 30-day mortality and morbidity.MethodsThe study included 272 patients diagnosed with acute PE, comprising 154 females and 118 males, with a mean age of 63.1 ± 16.8 years. Tpe/cTpe intervals were calculated from the electrocardiograms with a computer program after using a ruler or vernier caliper manual measuring tool to obtain highly sensitive measurements. The relationship between the electrocardiogram values and 30-days mortality and morbidity were measured.ResultsThe study group was divided into three groups according to cTpe intervals: Group 1, < 113 ms; Group 2, 113–133 ms; and Group 3, > 133 ms. White blood cell count and troponin T levels, corrected QT intervals with QRS complex durations, percentage of right ventricle dilatation with right/left-ventricular ratio, 30-day death, and combinations of these values were seen at a higher rate in Group 3 patients compared to the other groups. Kaplan–Meier analysis showed that the cTpe interval measured at > 126 ms could be used as a cut-off value in the prediction of mortality and morbidity. The cTpe cut-off values of 126 ms had sensivity, specificity, negative predictive value, and positive predictive value of 80.56 %, 59.32 %, 95.2 %, and 23.2 %, respectively.ConclusionscTpe interval could be a useful method in early risk stratification in patients with acute PE.
Highlights
The aim of this study was to examine the Tpeak-Tend (Tpe/corrected Tpe) interval, which is an indicator of transmural myocardial repolarization, measured non-invasively via electrocardiogram in patients with acute pulmonary embolism (PE), and to investigate the relationship with 30-day mortality and morbidity
Despite the development of several diagnostic and treatment methods for acute pulmonary embolism acute (PE), the condition continues to be a significant cause of cardiovascular morbidity and mortality [1, 2]
The mechanism for the appearance of ventricular repolarization following the onset of acute PE is unknown, but may involve the development of acute cor pulmonale caused by the enlargement of the right ventricle (RV) due to rapid RV pressure overload [9, 10]
Summary
The aim of this study was to examine the Tpeak-Tend (Tpe/corrected Tpe) interval, which is an indicator of transmural myocardial repolarization, measured non-invasively via electrocardiogram in patients with acute pulmonary embolism (PE), and to investigate the relationship with 30-day mortality and morbidity. Despite the development of several diagnostic and treatment methods for acute pulmonary embolism acute (PE), the condition continues to be a significant cause of cardiovascular morbidity and mortality [1, 2]. Several ECG markers of ventricular repolarization have been reported to identify high-risk patients with acute PE [8]. The mechanism for the appearance of ventricular repolarization following the onset of acute PE is unknown, but may involve the development of acute cor pulmonale caused by the enlargement of the right ventricle (RV) due to rapid RV pressure overload [9, 10]. The primary cause of death in severe PE is the
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