Abstract
BackgroundThe aim of this study was to assess the effect of the lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on overall survival and disease-free survival in patients with lung cancer treated with radical surgery.MethodsWe performed a retrospective review of patients with lung cancer who prospectively underwent radical resection between 2004 and 2012. Blood samples were taken as part of the preoperative workup. The inflammatory markers studied were absolute values of lymphocytes, monocytes, neutrophils and platelets, with subsequent calculation of ratios. Median follow-up was 52 months.ResultsTwo hundred and sixty-eight patients underwent surgery, of whom 218 (81.3%) were men. Mean age was 62.9 ± 8.7 years. A lymphocyte-to-monocyte ratio ≥ 2.5 was independently associated with longer disease-free survival (hazard ratio [HR] 0.476 (0.307–0.738), p = 0.001) and longer overall survival (HR, 0.546; 95% CI: 0.352–0.846; p = 0.007), in models adjusted for age, sex, stage, and type of resection. No other systemic inflammatory marker showed a significant association.ConclusionPreoperative LMR is an independent prognostic factor of overall survival and recurrence-free survival in patients with surgically-resected early stage lung cancer.
Highlights
The aim of this study was to assess the effect of the lymphocyte-to-monocyte ratio (LMR), neutrophilto-lymphocyte ratio and platelet-to-lymphocyte ratio on overall survival and disease-free survival in patients with lung cancer treated with radical surgery
Nutritional status is a prognostic factor in patients with lung cancer [3, 4], and our group has confirmed that nutritional status affects survival and postoperative outcomes in patients with lung cancer who undergo surgical resection [5]
Study population We retrospectively reviewed a cohort of 653 patients who were treated with radical lung resection between January 2004 and December 2012
Summary
The aim of this study was to assess the effect of the lymphocyte-to-monocyte ratio (LMR), neutrophilto-lymphocyte ratio and platelet-to-lymphocyte ratio on overall survival and disease-free survival in patients with lung cancer treated with radical surgery. Prognostic factors related not to the tumour itself but to the patient’s general health status have been studied, including nutritional status and inflammatory status. Nutritional status is a prognostic factor in patients with lung cancer [3, 4], and our group has confirmed that nutritional status affects survival and postoperative outcomes in patients with lung cancer who undergo surgical resection [5]. Another prognostic factor that has been associated with survival and complications is inflammatory status. Multiple parameters can be used to determine the inflammatory status of a patient with cancer, but blood
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