Abstract
The neutrophil/lymphocyte ratio (NLR) has been found to be predictive of survival outcome in a range of tumors. The purpose of this study was to investigate the prognostic value of pretreatment (NLR) in patients with laryngeal squamous cell carcinoma (SCC). A retrospective analysis of 140 patients with laryngeal SCC treated between 2005 and 2010 in the Hull and East Yorkshire Hospitals NHS Trust was carried out. Patient records were evaluated and both pretreatment neutrophil and lymphocyte counts were documented together with survival data, sex, smoking status, nodal classification, and disease staging. An elevated NLR was significantly associated with advanced disease stage (eg, node-positive and tumors stage III and IV). In addition, a high NLR was significantly associated with poor overall survival (OS) but not disease-free survival (DFS) on multivariate analysis, with the greatest significance seen in patients with the highest NLR. Pretreatment NLR may serve as a useful prognostic marker in laryngeal SCC; however, a large prospective study is required to determine an optimal NLR cutoff value. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1903-E1908, 2016.
Highlights
In England, the incidence of laryngeal cancer has fallen by 20% since 19901.Similar findings have been observed in Europe with a fall from 45,900 new cases in 2006 to 39,900 cases in 20122,3
neutrophil to lymphocyte ratio (NLR) was calculated as absolute neutrophil count divided by absolute lymphocyte count.[14,18]
Continuous data were expressed as medians with interquartile ranges and clinical stage was categorised into early
Summary
In England, the incidence of laryngeal cancer has fallen by 20% since 19901. Similar findings have been observed in Europe with a fall from 45,900 new cases in 2006 to 39,900 cases in 20122,3. Better public health promotion on the adverse effects of smoking and drinking alcohol is likely to be a major contribution to the observed decrease. Fo with laryngeal cancer has remained unchanged for the last two decades with a 5year relative survival of 65% in England[1]. In order to improve the survival outcome of laryngeal cancer patients, alternative ways of assessing the er best treatment plan are necessary. The purpose of this study was to investigate the prognostic value of pre-treatment (NLR) in laryngeal squamous cell carcinoma (LSCC) patients
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