Abstract
Inflammation plays a role in malignant pleural mesothelioma (MPM) prognosis and symptoms. We investigated the roles of the new and old inflammatory indexes and markers in MPM prognosis. Two hundred and ninety-two MPM patients (167 male and 125 female) were included in this retrospective study. Demographic parameters were collected from the patients' files. Kaplan-Meier curves and multivariate Cox regression analyses were used for the analysis of prognosis. The mean age of the patients was 58.4years. The mean survival time was 14.6±13.0months. Twenty-four potential prognostic factors associated with a poor outcome were calculated in the univariate analysis, and 16 potential prognostic factors were associated with a poor prognosis. These 16 potential prognostic factors were also analyzed in multivariate analysis. Multivariate analysis showed that increased age, stage 3-4 disease, the non-epithelial type, a low Karnofsky performance score, a high white blood cell count, and a low lymphocyte-to-monocyte ratio (LMR) were associated with a poor prognosis. The results of the multivariate analysis showed that a decreased LMR was associated with poor survival. Patients with LMR ≤2.6 had poor survival compared with those with LMR >2.6 (mean 9.6 vs. 17.0months, respectively; p=0.004). LMR is an independent marker of prognosis in patients with MPM and is superior to the other inflammation-based markers. The inexpensive nature and easy reproducibility of the hemogram should encourage the use of the LMR in clinical practice.
Highlights
Malignant pleural mesothelioma (MPM) is a rare aggressive tumor originating from the pleural mesothelium that is associated with poor survival, and there is limited knowledge concerning its natural history [1]
Twenty-four potential prognostic factors associated with a poor outcome were calculated in the univariate analysis, and 16 potential prognostic factors were associated with a poor prognosis
Multivariate analysis showed that increased age, stage 3–4 disease, the non-epithelial type, a low Karnofsky performance score, a high white blood cell count, and a low lymphocyte-to-monocyte ratio (LMR) were associated with a poor prognosis
Summary
Malignant pleural mesothelioma (MPM) is a rare aggressive tumor originating from the pleural mesothelium that is associated with poor survival, and there is limited knowledge concerning its natural history [1]. The European Organization for Research and Treatment of Cancer (EORTC) and Cancer and Leukemia Group B (CALGB) devised two prognostic scoring systems for use in patients with mesothelioma [7, 8]. These scoring systems are not routinely used for MPM prognosis because they are time-consuming and require costly equipment. Identification of parameters that are useful, easy, and inexpensive to measure for predicting MPM prognosis is needed These parameters may be useful for estimating the occurrence of malignant mesothelioma (MM) after asbestos exposure and predicting treatment options and results
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
