Abstract
Background: The objective of this study is to assess the prognostic value of lymph node metastasis distribution (LND) in locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT).Methods: This study included 179 patients with pathological stage III LARC who underwent nCRT followed by radical surgery. LND was classified into three groups: LND1, lymph node metastasis at the mesorectum (140/179, 78.2%); LND2, lymph node metastasis along the inferior mesenteric artery trunk nodes (26/179, 14.5%); LND3, lymph node metastasis at the origin of the IMA (13/179, 7.3%). Clinicopathologic characteristics were analyzed to identify independent prognostic factors.Result: LND showed better stratification for 3-year DFS (LND1 66.8, LND2 50, and LND3 15.4%, P < 0.01) compared to the ypN (3-year DFS: N1 59.9 and N2 60.3%, P = 0.34) and ypTNM (3-year DFS: IIIA 68.6%, IIIB 57.5%, and IIIC 53.5, P = 0.19) staging systems. Similar results were found for 3-year LRFS and DMFS. According to multivariate survival analysis, LND was shown to be an independent prognostic factor for DFS, LRFS, and DMFS in patients with positive lymph nodes (P < 0.01, in all cases).Conclusion: LND is an independent prognostic factor in stage III rectal cancer after nCRT. LND can be used as a supplementary indicator for the ypTNM staging system in patients with LARC after nCRT.
Highlights
Neoadjuvant chemoradiotherapy followed by total mesorectal excision (TME) is widely used as a multimodal treatment for rectal cancer
The latest guidelines recommend Neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery as the standard treatment for patients with locally advanced rectal cancer (LARC) [4, 5]
The current study demonstrated the prognostic value of lymph node metastasis distribution (LND) in patients with LARC after nCRT
Summary
Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME) is widely used as a multimodal treatment for rectal cancer. This approach has achieved good results with respect to tumor downstaging, reducing local recurrence, and improving R0 resection [1,2,3]. The ypTNM staging system is the most common indicator for evaluating the prognosis of patients with LARC after nCRT It has certain limitations in the assessment of prognosis due to the influence of radiotherapy [6, 7]. The objective of this study is to assess the prognostic value of lymph node metastasis distribution (LND) in locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT)
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