Prognostic value of systemic inflammatory response syndrome and serum concentrations of acute phase proteins, cholesterol, and total thyroxine in cats with panleukopenia.

Matteo Petini,Michele Drigo,Andrea Zoia

doi:10.1111/jvim.15704

Abstract

BackgroundFeline parvovirus (FPV) is a common and potentially lethal infectious agent in cats.ObjectiveTo assess the prognostic value of age, neuter status, serum concentrations of serum amyloid A (SAA), haptoglobin, cholesterol and total thyroxine (tT4), and the presence of systemic inflammatory response syndrome (SIRS) in cats with panleukopenia.AnimalsClient‐owned cats with FPV infection diagnosed by a positive fecal ELISA test, positive PCR on feces or blood or both.MethodsRetrospective cohort study. The electronic medical database was searched for cats with FPV infection presented between January 2010 and January 2018. Cats were divided into survivors and nonsurvivors according to their survival status 28 days after hospital admission. The prognostic importance of each variable was investigated univariately and by multivariable Cox's proportional‐hazards regression. Finally, receiver operator characteristic (ROC) curve analysis was used to identify the best cutoff value for discriminating survivors from nonsurvivors for the statistically significant prognostic predictors identified by multivariable analysis.ResultsSeventy cats were enrolled in the study. Multivariable analysis determined that only serum tT4 concentration at hospital admission was significantly (P = .01) associated with survival. A cutoff value of 0.82 μg/dL was identified by ROC curve analysis for serum tT4 concentration in discriminating survivors from nonsurvivors. Sensitivity at this cutoff was 73.9% and specificity was 82.9% (area under the curve, 0.783; 95% confidence interval, 0.668‐0.873; P < .0001).Conclusion and Clinical RelevanceSerum tT4 concentration at hospital admission has prognostic value in cats with FPV infection.

Highlights

Parvovirus is an infectious agent in cats and in other mammalian species.[1,2] The virus is transmitted to susceptible animals by indirect contact with contaminated material.[1]
To improve knowledge about the prognosis of panleukopenia in cats, our aim was to assess the prognostic value of the presence of systemic inflammatory response syndrome (SIRS) and the concentrations of serum amyloid A (SAA), haptoglobin, cholesterol, and total thyroxine (tT4) in Feline parvovirus (FPV)-infected cats at hospital admission
The optimal cutoff value identified by receiver operator characteristic (ROC) curve analysis for serum tT4 concentration was 0.82 μg/dL

Summary

Introduction

Parvovirus is an infectious agent in cats and in other mammalian species.[1,2] The virus is transmitted to susceptible animals by indirect contact with contaminated material.[1]. Feline parvovirus (FPV) is a common and potentially lethal infectious agent in cats. Receiver operator characteristic (ROC) curve analysis was used to identify the best cutoff value for discriminating survivors from nonsurvivors for the statistically significant prognostic predictors identified by multivariable analysis. A cutoff value of 0.82 μg/dL was identified by ROC curve analysis for serum tT4 concentration in discriminating survivors from nonsurvivors. Sensitivity at this cutoff was 73.9% and specificity was 82.9% (area under the curve, 0.783; 95% confidence interval, 0.668-0.873; P < .0001). Conclusion and Clinical Relevance: Serum tT4 concentration at hospital admission has prognostic value in cats with FPV infection

Objectives

Methods

Results

Conclusion