Abstract
ObjectiveTo investigate the prognostic value of serum amyloid A (SAA) in the patients with Corona Virus Disease 2019 (COVID-19).MethodsThe medical data of 89 COVID-19 patients admitted to Renmin Hospital of Wuhan University from January 3, 2020 to February 26, 2020 were collected. Eighty-nine cases were divided into survival group (53 cases) and non-survival group (36 cases) according to the results of 28-day follow-up. The SAA levels of all patients were recorded and compared on 1 day after admission (before treatment) and 3 days, 5 days, and 7 days after treatment. The ROC curve was drawn to analyze the prognosis of patients with COVID-19 by SAA.ResultsThe difference of comparison of SAA between survival group and non-survival group before treatment was not statistically significant, Z1 = − 1.426, P = 0.154. The Z1 values (Z1 is the Z value of the rank sum test) of the two groups of patients at 3 days, 5 days, and 7 days after treatment were − 5.569, − 6.967, and − 7.542, respectively. The P values were all less than 0.001, and the difference was statistically significant. The ROC curve results showed that SAA has higher sensitivity to the prognostic value of 1 day (before treatment), 3 days, 5 days, and 7 days after treatment, with values of 0.806, 0.972, 0.861, and 0.961, respectively. Compared with SAA on the 7th day and C-reactive protein, leukocyte count, neutrophil count, lymphocyte count, and hemoglobin on the 7th day, the sensitivities were: 96.1%, 83.3%, 88.3%, 83.3%, 67.9%, and 83.0%, respectively, of which SAA has the highest sensitivity.ConclusionSAA can be used as a predictor of the prognosis in patients with COVID-19.
Highlights
Research methodSince December 2019, cases of pneumonia of unknown origin have been reported in Wuhan, Hubei Province
COVID-19 is a serious infectious disease caused by SARSCoV-2
Similar to severe acute respiratory syndrome (SARS) and MERS, COVID-19 has atypical early symptoms [11, 12], most of which are characterized by fever, dry cough, and fatigue
Summary
Research methodSince December 2019, cases of pneumonia of unknown origin have been reported in Wuhan, Hubei Province. Until 5 pm on March 10, 2020, a total of 113,702 COVID-19 cases have been diagnosed and 4012 deaths all over the world, affecting 110 countries [2, 3], with a fatality rate of 3.53%, and a higher mortality rate among older men with severe underlying diseases [4]. It is important for those patients with COVID-19 to judge the prognosis of patients accurately, and to take more active and effective treatment measures. This article analyzes the dynamic changes of SAA in 89 patients with COVID-19 in Renmin Hospital of Wuhan University to evaluate the clinical prognostic value of SAA, which is reported as follows
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